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Colon Cancer Research Paper

Reducing colorectal cancer risk

❶Learn about the risk factors for colorectal cancer and what you might be able to do to help lower your risk. Advanced Cancer and Caregivers.


Clinical Colorectal Cancer
Early detection

The stages range from I to IV, with I being the least advanced and harmful to IV being the worst, as it has metastasized. It can be cured if it is caught early enough. There are quite a few things that contribute to this condition.

As with most cancers, the risk increases with time and a family history of colon cancer. Men are more likely to get it than women, with African-American men having the highest risk in the United States. Smokers and physically inactive people have higher risk.

Diets that are high in fiber, fruits and vegetables have a lower risk of this. However, diets high in red meat and fat have an increased risk. Hereditary conditions that will increase the risk of colon cancer include a general family history, Familial adenomatous polyposis, and Hereditary nonpolyposis colorectal cancer.

Familial adenomatous polyposis increases the risk of developing colon cancer to almost certain. The disorder causes a person to have thousands of polyps, causing from an early age anemia due to the loss of blood in the feces. Later on, the person will most likely develop cancer. Hereditary nonpolyposis colorectal cancer is also called Lynch Syndrome.

Symptoms may be full on and complete or could be nearly nonexistent. Symptoms include a change in bowel patterns, blood in feces, and bowel obstruction by the tumor.

Blood is usually the best indicator because it is specific to colon cancer. Bowel obstruction is fairy rare, other symptoms would usually show before this. People with FAP, an inherited condition that greatly increases their risk of gastrointestinal cancer, who took the drugs erlotinib Tarceva and sulindac Aflodac saw a substantial decrease in the number of precancerous lesions in the colon and rectum. Fusobacterium, found in the stomach and intestines, may help fuel the growth of colorectal cancer and metastases.

In a mouse model of colorectal cancer, using antibiotics to kill these bacteria slowed tumor growth. Proactive, low-tech outreach approaches can help increase the number of people who get screened for colorectal cancer with a colonoscopy or home stool test and complete the appropriate follow-up. A shorter course of chemotherapy following surgery may be preferred to longer treatment for some patients with colon cancer, results of an international collaborative study suggest.

Philip Rosenberg and William Anderson of NCI discuss a recent study on which they were coauthors that reported an increase in colorectal cancer incidence among adults under age 50 in the United States.

In a study of an immune therapy for colorectal cancer that involved a single patient, researchers identified a method for targeting the cancer-causing protein produced by a mutant form of the KRAS gene.

A blog post on a study showing that in patients with metastatic colorectal cancer, the location in the colon where the tumor originated appears to strongly influence how long patients live. African Americans younger than age 50 had significantly worse 5-year survival rates at every stage of disease compared with young white and Hispanic patients, a new study shows.

In a small clinical trial of people with an inherited condition that greatly increases gastrointestinal cancer risk, a two-drug combination shrank precancerous lesions in the duodenum.

A missing hormone in obese mice may help explain a longstanding association between obesity and an increased risk of colorectal cancer in humans. The FDA has approved a single drug that combines trifluridine and tipiracil to treat patients with metastatic colorectal cancer whose disease progressed after standard treatment. In an international randomized phase III trial, the investigational drug TAS extended the lives of patients with metastatic colorectal cancer whose disease had progressed following standard therapies.

A new study suggests that dense bacterial communities called biofilms may promote the development of some colorectal cancers. New research suggests that identifying specific changes in the gut microbiome could potentially help screen patients for colorectal cancer. Investigators who analyzed 95 human colorectal tumor samples have determined how gene alterations identified in previous analyses of the same samples are expressed at the protein level. The integration of proteomic and genomic data, or proteogenomics, provides a more comprehensive view of the biological features that drive cancer than genomic analysis alone.

In a large randomized trial involving healthy men and women aged 55 to 74, sigmoidoscopy substantially reduced the incidence of and mortality from colorectal cancer.

Long-term results from the National Polyp Study confirm that removing precancerous adenomas not only reduces the risk of colorectal cancer but also reduces the number of deaths from the disease by more than half. Findings from the first large clinical trial of its kind indicate that taking high doses of aspirin daily for at least 2 years substantially reduces the risk of colorectal cancer among people at increased risk of the disease.

In a randomized phase III trial, the addition of the targeted therapy cetuximab to oxaliplatin and fluoropyrimidine chemotherapy did not prolong survival or time to disease progression of patients with advanced colorectal cancer. The results were published on June 5, in The Lancet. Cancer patients who receive the targeted therapy bevacizumab Avastin in combination with chemotherapy are at increased risk of serious side effects that may lead to death, according to a meta-analysis of 16 clinical trials that was published February 2, , in JAMA.

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Colon Cancer Research Papers discuss how this cancer develops in the body. Cancer is the number two leading cause of death in the United States. The disease can strike almost any part of the body and is classified as an abnormal growth of cells.

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Colorectal cancer, more commonly known as colon cancer, is a common form of cancer; It is the third most common type of cancer and the second most lethal. It is fairly common due to the numerous causes and contact with foreign substances. Cancer is the condition of where cells do not cease mitosis, and continue to duplicate in tumors.5/5(1).

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- Colorectal cancer: Colorectal cancer, also known as bowel cancer, is found in the colon and the rectum and has become one of the most common forms of malignant cancer (Cross & Underwood, ). . Feb 21,  · Surgery that saves the anal sphincter muscle that controls the passing of stool is a rectal cancer research interest. Sometimes when colorectal cancer recurs (comes back), it spreads to the peritoneum (the thin lining of the abdominal cavity and organs inside the abdomen). These cancers are often hard to treat.

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This research paper will study colon cancer in detail including its signs and symptoms, causes, pathogenesis, diagnosis, prevention, management, prognosis and epidemiology. Signs and symptoms Colon cancer has varied signs and symptoms depending on its location in the large intestines, however, several signs and symptoms are common, they include. Thanks to improvements in prevention, early detection, and treatment, more than a million people in the US count themselves as survivors of colon or rectum cancer (also called colorectal cancer).